The Faculty of Technology organized a seminar on “The Ecology and virulence of cryptococcus neoformans in Vietnam”

(VLU, 03/8/2021On July 30, the Faculty of Technology held a seminar on the topic “The Ecology and virulence of Cryptococcus neoformans in Vietnam”, with Dr. Phan Hai Trieu as a presenter. Over 80 students and attendees of the seminar learned more about fungi, particularly Cryptococcus neoformans, as well as methods of collecting samples, performing PCR, and analyzing the results.

As part of its commitment to academic excellence, on 30.07.2021, the Faculty of Technology of Van Lang University organized an academic seminar about "The Ecology and virulence of Cryptococcus neoformans in Vietnam”. With 10-year experience participating in international clinical research at Oxford University, Dr. Phan Hai Trieu made significant contributions to proof of transcriptional differences between environmental and clinical Cryptococcus neoformans strains by using Galleria mellonella (wax worm) infection model and elaborate genetic testing.

vlu cn hoi thao sinh thai g

Fungi exist in millions of different types around the world, from edible mushrooms to those that cause diseases, including many that can't be seen with the naked eye. There are hundreds of types of fungi that cause common diseases in humans, such as fungal nail/skin infections, asthma and allergies. Further, some fungi cause diseases that are dangerous to human health such as pneumonia, septicemia (blood infection), meningitis, etc.

In Vietnam, Cryptococcus neoformans fungi are responsible for about 1,000-2,500 cases of meningitis every year. Cryptococcus spp are environmental saprophytes, reproduce by budding, and are found in stool pigeons, bird droppings, air, and soil cavities. When infected by inhaling the fungus from the environment, people are susceptible to pneumonia, leading to meningitis and a mortality rate of 30% in 10 weeks.

vlu cn hoi thao sinh thai hClimate warming appears to be related to the expansion of mushroom habitats, according to Dr. Phan Hai Trieu. Wildlife may be affected by some fungi when they expand their range.

During the exchange, Dr. Phan Hai Trieu also introduced to attendees to basic knowledge about fungi, fungal diseases, mechanisms to protect the body from fungal infection, C. neoformans meningitis and treatment. Dr. Phan Hai Trieu provided insights into a series of studies comparing the virulence of C. neoformans obtained from the environment and patients through modern methods.

During his comprehensive research and conducting elaborate experiments, Dr. Phan Hai Trieu has reached many useful conclusions, such as the clinical C. neoformans is more virulent than Cryptococcus spp isolated from the environment; the clinical C. neoformans is more virulent than the environmental C. neoformans in the G. mellonella model; comparative transcriptomics revealed 1700 genes that were differentially expressed between clinical and environmental isolates, with the clinical C. neoformans virulence genes being expressed 2 to 45 times higher than the environmental C. neoformans virulence genes.

It can be said that this is a topic that is in depth, covering a wide range of topics about biology, the environment, and medicine, providing attendees with useful perspectives about those subjects and suggesting research directions for students of the Faculty of Technology in the future.

vlu cn hoi thao sinh thai bIt was a lively conference with much academic dialogue among Dr. Phan Hai Trieu and faculty and students of the Faculty of Technology.

Dr. Nguyen Huu Hung, Vice Dean of the Faculty of Technology, summarized: "Dr. Phan Hai Trieu will bring many important lessons related to growth, pathogenesis, and fungal epidemiology, as well as experience in big data analysis and culture modeling to the Faculty of Technology students. For those working in molecular biotechnology, this is a rather complicated tool. This, hopefully, will be a motivator and opportunity for Faculty of Technology students to explore and gain an understanding of modern research methodologies, as well as cultivate a passion for research during their time at Van Lang University."

Next Friday, August 6, 2021, at 13:30, the Faculty of Technology will continue to organize a scientific seminar to discuss stem cell applications in cosmetic care and treatment.

Reporter: Hoai Anh


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